A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration

Quirk, M. C., Sosulski, D. L., Feierstein, C. E., Uchida, N., Mainen, Z. F. (November 2009) A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration. Frontiers in Systems Neuroscience, 3. p. 13. ISSN ISSN 1662-5137

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URL: http://www.ncbi.nlm.nih.gov/pubmed/20057934

DOI: 10.3389/neuro.06.013.2009

Abstract

Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC-FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states.

Item Type:	Paper
Uncontrolled Keywords:	schizophrenia, depression, fast-spiking interneuron, motivation, parvalbumin, psychosis
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neocortical interneurons organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > orbitofrontal cortex organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Feierstein, Claudia E. Mainen, Zachary F. Quirk, Michael C. Uchida, Naoshige
Communities:	CSHL labs > Mainen lab School of Biological Sciences > Publications
Depositing User:	Matt Covey
Date:	3 November 2009
Date Deposited:	21 Feb 2013 17:13
Last Modified:	22 Sep 2014 18:33
PMCID:	PMC2802551
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27355

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