Ren, J., Martienssen, R. A. (August 2012) Silent decision: HP1 protein escorts heterochromatic RNAs to their destiny. Embo Journal, 31 (15). pp. 3237-8. ISSN 0261-4189
Abstract
Heterochromatin is classically perceived to be refractory to transcription because of its compact structure. However, Keller et al (2012) now demonstrated that heterochromatic transcripts can accumulate even when heterochromatin is normally packaged. By tracking down the fate of these heterochromatic RNAs, they revealed a new post-transcriptional mechanism of silencing in heterochromatin that involves the dynamic turnover of HP1Swi6 between its free, chromatin-bound and RNA-bound forms. The latter form escorts heterochromatic RNA to degradation...
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | gene maintenance mechanisms disinhibition G protein-coupled receptor neuropathic pain oligomer spinal cord heterochromatin protein 1 RNA article gene silencing genetic transcription heterochromatin human molecular dynamics molecular mechanics nonhuman priority journal protein structure Rattus |
| Subjects: | bioinformatics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNA regulation |
| CSHL Authors: | |
| Communities: | CSHL labs > Martienssen lab CSHL Post Doctoral Fellows |
| Depositing User: | Matt Covey |
| Date: | 1 August 2012 |
| Date Deposited: | 30 Jan 2013 14:33 |
| Last Modified: | 05 Jun 2013 20:03 |
| PMCID: | PMC3411077 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27027 |
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