Primary cells suppress oncogene-dependent apoptosis

Duelli, D. M., Lazebnik, Y. A. (2000) Primary cells suppress oncogene-dependent apoptosis. Nature Cell Biology, 2 (11). pp. 859-862. ISSN 1465-7392

Abstract

Oncogenes that promote cell-cycle progression also sensitize cells to agents that induce apoptosis, possibly by inactivating inhibitors that ordinarily provide protection against cell death. Here we show that the adenoviral oncogene E1A sensitizes cells to an anti-cancer drug by at least two pathways. One establishes a link between the drug and pro-apoptotic factors, but is not sufficient for sensitization without the second pathway, which suppresses inhibitors of apoptosis.

Item Type: Paper
Uncontrolled Keywords: Adenovirus E1A Proteins Apoptosis Cells, Cultured Cytochrome c Group Etoposide Fibroblasts HeLa Cells Humans Jurkat Cells Nucleic Acid Synthesis Inhibitors Oncogenes Proto-Oncogene Proteins Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc bcl-2-Associated X Protein
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene
CSHL Authors:
Communities: CSHL labs > Labeznik lab
Depositing User: Matt Covey
Date: 2000
Date Deposited: 12 Dec 2012 17:31
Last Modified: 12 Dec 2012 17:31
Related URLs:
URI: https://repository.cshl.edu/id/eprint/26391

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