The dynamics of chromosome organization and gene regulation

Spector, D. L. (2003) The dynamics of chromosome organization and gene regulation. Annual Review of Biochemistry, 72. pp. 573-608. ISSN 0066-4154

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URL: http://www.ncbi.nlm.nih.gov/pubmed/14527325

DOI: 10.1146/annurev.biochem.72.121801.161724

Abstract

With the sequence of the human genome now complete, studies must focus on how the genome is functionally organized within the confines of the cell nucleus and the dynamic interplay between the genome and its regulatory factors to effectively control gene expression and silencing. In this review I describe our current state of knowledge with regard to the organization of chromosomes within the nucleus and the positioning of active versus inactive genes. In addition, I discuss studies on the dynamics of chromosomes and specific genetic loci within living cells and its relationship to gene activity and the cell cycle. Furthermore, our current understanding of the distribution and dynamics of RNA polymerase II transcription factors is discussed in relation to chromosomal loci and other nuclear domains.

Item Type:	Paper
Uncontrolled Keywords:	Animals Cell Cycle Cell Nucleus Chromosomes Gene Expression Regulation Gene Silencing Genome Humans Mitosis RNA Polymerase II Transcription Factors Transcription, Genetic
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosome bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function > chromosome bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > chromosomes, structure and function bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function
CSHL Authors:	Spector, David L.
Communities:	CSHL labs > Spector lab
Depositing User:	Matt Covey
Date:	2003
Date Deposited:	10 Dec 2012 20:01
Last Modified:	29 Jan 2015 16:10
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/26357

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