He, L., Thomson, J. M., Hemann, M. T., Hernando-Monge, E., Mu, D., Goodson, S., Powers, S., Cordon-Cardo, C., Lowe, S. W., Hannon, G. J., Hammond, S. M. (June 2005) A microRNA polycistron as a potential human oncogene. Nature, 435 (7043). pp. 828-33. ISSN 0028-0836
Abstract
To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding RNAs remains largely obscure. One cluster of microRNAs, the mir-17-92 polycistron, is located in a region of DNA that is amplified in human B-cell lymphomas. Here we compared B-cell lymphoma samples and cell lines to normal tissues, and found that the levels of the primary or mature microRNAs derived from the mir-17-92 locus are often substantially increased in these cancers. Enforced expression of the mir-17-92 cluster acted with c-myc expression to accelerate tumour development in a mouse B-cell lymphoma model. Tumours derived from haematopoietic stem cells expressing a subset of the mir-17-92 cluster and c-myc could be distinguished by an absence of apoptosis that was otherwise prevalent in c-myc-induced lymphomas. Together, these studies indicate that non-coding RNAs, specifically microRNAs, can modulate tumour formation, and implicate the mir-17-92 cluster as a potential human oncogene.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Cell Line Tumor Disease Models Animal Gene Expression Profiling Gene Expression Regulation Neoplastic Genes genetics Genes myc genetics Humans Lymphoma B Cell genetics Mice MicroRNAs genetics Molecular Sequence Data Multigene Family genetics Oncogenes genetics Phenotype Proto Oncogene Proteins c myc genetics metabolism RNA Messenger genetics metabolism |
| Subjects: | diseases & disorders > cancer > cancer types > B cell lymphoma diseases & disorders > cancer diseases & disorders organism description > animal > mammal > primates > hominids > human bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > ncRNA |
| CSHL Authors: | |
| Communities: | CSHL labs > Hannon lab CSHL labs > Lowe lab CSHL labs > Powers lab |
| Depositing User: | Editor Margaret Fantz |
| Date: | 9 June 2005 |
| Date Deposited: | 17 Apr 2012 18:14 |
| Last Modified: | 01 Mar 2013 19:49 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26105 |
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