Asari, H., Zador, A. M. (August 2009) Long-Lasting Context Dependence Constrains Neural Encoding Models in Rodent Auditory Cortex. J Neurophysiol, 102 (5). pp. 2638-56.
Abstract
Acoustic processing requires integration over time. We have used in vivo intracellular recording to measure neuronal integration times in anesthetized rats. Using natural sounds and other stimuli, we found that synaptic inputs to auditory cortical neurons showed a rather long context-dependence, up to four seconds or longer ({tau}~1 s), even though sound-evoked excitatory and inhibitory conductances per se rarely lasted longer than ~100 ms. Thalamic neurons showed only a much faster form of adaptation with a decay constant {tau}<100 ms, indicating that the long-lasting form originated from presynaptic mechanisms in the cortex, such as synaptic depression. Restricting knowledge of the stimulus history to only a few hundred milliseconds reduced the predictable response component to about half of that of the optimal infinite-history model. Our results demonstrate the importance of longrange temporal effects in auditory cortex, and suggest a potential neural substrate for auditory processing that requires integration over time scales of seconds or longer, such as stream segregation.
| Item Type: | Paper |
|---|---|
| Subjects: | organs, tissues, organelles, cell types and functions > tissues types and functions > auditory cortex bioinformatics > computational biology organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organism description > animal > mammal > rodent > rat organism description > animal > mammal > rodent > rat |
| CSHL Authors: | |
| Communities: | CSHL labs > Zador lab School of Biological Sciences > Publications |
| Depositing User: | Leigh Johnson |
| Date: | 12 August 2009 |
| Date Deposited: | 28 Mar 2012 19:02 |
| Last Modified: | 22 Sep 2014 16:46 |
| PMCID: | PMC2777827 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/25605 |
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