Chapter 3 - Genetics in learning and memory

Wang, Yalin, Dubnau, Josh, Tully, Tim, Zhong, Yi (2007) Chapter 3 - Genetics in learning and memory. In: Neurobiology of Learning and Memory (Second Edition). Academic Press, Burlington, pp. 103-127. ISBN 978-0-12-372540-0

DOI: 10.1016/b978-012372540-0/50004-2


The power of genetics has been clearly demonstrated in studies of embryonic development. Systematic searches for mutant phenotypes during embyogenesis in Drosophila (Nusslein-Volhard and Wieschaus, 1980; Johnston and Nusslein-Volhard, 1992; Wieschaus, 1996) and zebrafish (Grunwald and Eisen, 2002) have uncovered most of the genes controlling embryonic pattern formation. The number of genes involved is limited, and they can be categorized into specific functional groups according to their phenotypic effects. Many of the corresponding genes have been characterized molecularly, thereby identifying components of gene regulation and cell signaling pathways. Genes first discov- ered in flies have subsequently been identified in vertebrates, and basic genetic mechanisms controlling early development of invertebrates have been shown to be conserved in vertebrate systems. Thus, a driving force behind analysis of development has been gene discovery in flies, which in turn has provided experimental and conceptual tools to dissect mechanisms of morphogenesis in both invertebrate and vertebrate species.

Item Type: Book Section
Subjects: organism description > animal > insect > Drosophila
organism description > animal > developmental stage > embryo
organs, tissues, organelles, cell types and functions > tissues types and functions > embryogenesis
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
CSHL Authors:
Communities: CSHL labs > Zhong lab
CSHL labs > Dubnau lab
CSHL labs > Tully lab
Depositing User: CSHL Librarian
Date: 2007
Date Deposited: 29 Mar 2012 15:54
Last Modified: 10 Apr 2018 20:42

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