Tonks, N. K., Muthuswamy, S. K. (March 2007) A Brake Becomes an Accelerator: PTP1B-A New Therapeutic Target for Breast Cancer. Cancer Cell, 11 (3). pp. 214-6. ISSN 1535-6108 (Print)
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Abstract
The protein tyrosine phosphatase PTP1B, previously recognized for its role in downregulating insulin and leptin signaling, has now been shown to function as a positive regulator of signaling events associated with breast tumorigenesis. Inhibitors of PTP1B that have been developed as drug candidates for treatment of diabetes and obesity may offer new avenues for the treatment of breast cancer.
| Item Type: | Paper |
|---|---|
| Subjects: | diseases & disorders > cancer > cancer types > breast cancer diseases & disorders > nutritional and metabolic diseases > diabetes bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase |
| CSHL Authors: | |
| Communities: | CSHL labs > Muthuswamy lab CSHL labs > Tonks lab |
| Depositing User: | CSHL Librarian |
| Date: | March 2007 |
| Date Deposited: | 01 Nov 2011 18:54 |
| Last Modified: | 21 Feb 2017 20:28 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/23158 |
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