Manganas, L. N., Zhang, X. Y., Li, Y., Hazel, R. D., Smith, S. D., Wagshul, M. E., Henn, F. A., Benveniste, H., Djuric, P. M., Enikolopov, G. N., Maletic-Savatic, M. (November 2007) Magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain. Science, 318 (5852). pp. 980-985. ISSN 0036-8075
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Abstract
The identification of neural stem and progenitor cells (NPCs) by in vivo brain imaging could have important implications for diagnostic, prognostic, and therapeutic purposes. We describe a metabolic biomarker for the detection and quantification of NPCs in the human brain in vivo. We used proton nuclear magnetic resonance spectroscopy to identify and characterize a biomarker in which NPCs are enriched and demonstrated its use as a reference for monitoring neurogenesis. To detect low concentrations of NPCs in vivo, we developed a signal processing method that enabled the use of magnetic resonance spectroscopy for the analysis of the NPC biomarker in both the rodent brain and the hippocampus of live humans. Our findings thus open the possibility of investigating the role of NPCs and neurogenesis in a wide variety of human brain disorders.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM N-ACETYLASPARTATE DENTATE GYRUS ADULT BRAIN NEUROGENESIS STEM PROLIFERATION HIPPOCAMPUS DECREASE THERAPY |
| Subjects: | Investigative techniques and equipment > biomarker organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > tissues types and functions > hippocampus therapies > stem cells |
| CSHL Authors: | |
| Communities: | CSHL labs > Enikopolov lab CSHL labs > Henn lab |
| Depositing User: | CSHL Librarian |
| Date: | November 2007 |
| Date Deposited: | 09 Nov 2011 20:56 |
| Last Modified: | 03 Oct 2019 13:45 |
| PMCID: | PMC4039561 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/23092 |
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