He, L., He, X., Lowe, S. W., Hannon, G. J.
(November 2007)
microRNAs join the p53 network - another piece in the tumour-suppression puzzle.
Nat Rev Cancer, 7 (11).
pp. 819-822.
ISSN 1474-1768 (Electronic)
Abstract
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.
| Item Type: |
Paper
|
| Subjects: |
diseases & disorders > cancer
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > miRNA
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > miR-34
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p53 |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Hannon lab
CSHL labs > Lowe lab |
| Depositing User: |
CSHL Librarian
|
| Date: |
November 2007 |
| Date Deposited: |
15 Nov 2011 15:29 |
| Last Modified: |
02 Dec 2016 15:52 |
| PMCID: |
PMC4053212 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/23031 |
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