Identification of linotte, a new gene affecting learning and memory in Drosophila melanogaster

Dura, J. M., Preat, T., Tully, T. (October 2007) Identification of linotte, a new gene affecting learning and memory in Drosophila melanogaster. Journal of Neurogenetics, 21 (4). pp. 307-320. ISSN 0167-7063

DOI: 10.1080/01677060701693479


We describe the identification of linotte, a new autosomal gene in Drosophila involved with learning and memory. The linotte' mutant was derived from a PlacW transposon mutagenesis and was screened for three-hour memory deficits after classical conditioning of an olfactory avoidance response. Sensory and motor systems (olfactory acuity and shock reactivity) required for the classical conditioning experiments were normal in mutant linotte' flies-indicating that the mutation disrupts learning/memory specifically. A chromosomal deficiency of the 37D region, where the linotte'P insert was localized in situ, failed to complement linotte's memory defect, and flies from two lines homozygous for independent PlacW excisions show normal memory-indicating that the P insertion is responsible for the mutant phenotype. Additional behavior-genetic data suggest that linotte' gene is non-vital.

Item Type: Paper
Uncontrolled Keywords: classical conditioning olfactory avoidance response transposon-tagging mutagenesis CYCLIC-AMP PHOSPHODIESTERASE ADENYLATE-CYCLASE RUTABAGA MUTANT MUTAGENESIS MUTATIONS GENOME LOCUS
Subjects: organism description > animal > insect > Drosophila
organism description > animal behavior
organism description > animal behavior > learning
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > linotte gene
organism description > animal behavior > memory
CSHL Authors:
Communities: CSHL labs > Tully lab
Depositing User: CSHL Librarian
Date: October 2007
Date Deposited: 15 Nov 2011 16:28
Last Modified: 22 Mar 2018 19:39
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