Dura, J. M., Preat, T., Tully, T. (October 2007) Identification of linotte, a new gene affecting learning and memory in Drosophila melanogaster. Journal of Neurogenetics, 21 (4). pp. 307-320. ISSN 0167-7063
Abstract
We describe the identification of linotte, a new autosomal gene in Drosophila involved with learning and memory. The linotte' mutant was derived from a PlacW transposon mutagenesis and was screened for three-hour memory deficits after classical conditioning of an olfactory avoidance response. Sensory and motor systems (olfactory acuity and shock reactivity) required for the classical conditioning experiments were normal in mutant linotte' flies-indicating that the mutation disrupts learning/memory specifically. A chromosomal deficiency of the 37D region, where the linotte'P insert was localized in situ, failed to complement linotte's memory defect, and flies from two lines homozygous for independent PlacW excisions show normal memory-indicating that the P insertion is responsible for the mutant phenotype. Additional behavior-genetic data suggest that linotte' gene is non-vital.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | classical conditioning olfactory avoidance response transposon-tagging mutagenesis CYCLIC-AMP PHOSPHODIESTERASE ADENYLATE-CYCLASE RUTABAGA MUTANT MUTAGENESIS MUTATIONS GENOME LOCUS |
| Subjects: | organism description > animal > insect > Drosophila organism description > animal behavior organism description > animal behavior > learning bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > linotte gene organism description > animal behavior > memory |
| CSHL Authors: | |
| Communities: | CSHL labs > Tully lab |
| Depositing User: | CSHL Librarian |
| Date: | October 2007 |
| Date Deposited: | 15 Nov 2011 16:28 |
| Last Modified: | 22 Mar 2018 19:39 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/23006 |
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