Demas, J., Cline, H. T. (January 2007) The blu Blur: mutation of a vesicular glutamate transporter reduces the resolution of zebrafish vision. Neuron, 53 (1). pp. 4-6. ISSN 0896-6273 (Print)
Abstract
Vesicular transporters mediate the packaging of neurotransmitters into synaptic vesicles and can therefore control the amount of neurotransmitter released into the synaptic cleft. In this issue of Neuron, Smear et al. demonstrate that mutation of a vesicular glutamate transporter (Vglut) found in the retinal ganglion cells (RGCs) of zebrafish alters both the synaptic transmission and connectivity between RGCs and their targets, limiting the transfer of visually evoked activity from RGCs and degrading behaviors that depend on high-acuity vision.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Glutamic Acid/metabolism Mutation/ genetics Neural Pathways/cytology/metabolism/physiopathology Retinal Ganglion Cells/ metabolism/ultrastructure Synaptic Transmission/ genetics Vesicular Glutamate Transport Proteins/ genetics Vision/genetics Vision Disorders/genetics/metabolism/physiopathology Zebrafish/anatomy & histology/ metabolism |
| Subjects: | organism description > animal behavior > visual > seeing organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse organism description > animal behavior > vision organism description > animal behavior > visual organism description > animal > fish > zebrafish |
| CSHL Authors: | |
| Communities: | CSHL labs > Cline lab |
| Depositing User: | CSHL Librarian |
| Date: | 4 January 2007 |
| Date Deposited: | 30 Nov 2011 20:06 |
| Last Modified: | 22 Mar 2018 16:30 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22996 |
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