Keyes, W. M., Vogel, H., Koster, M. I., Guo, X., Qi, Y., Petherbridge, K. M., Roop, D. R., Bradley, A., Mills, A. A. (May 2006) p63 heterozygous mutant mice are not prone to spontaneous or chemically induced tumors. Proc Natl Acad Sci U S A, 103 (22). pp. 8435-40. ISSN 0027-8424 (Print)
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Abstract
Homology between p63 and p53 has suggested that these proteins might function similarly. However, the majority of data from human tumors have not supported a similar role for p63 in tumor suppression. To investigate this issue, we studied spontaneous tumorigenesis in p63+/- mice in both WT and p53-compromised backgrounds. We found that p63+/- mice were not tumor prone and mice heterozygous for both p63 and p53 had fewer tumors than p53+/- mice. The rare tumors that developed in mice with compromised p63 were also distinct from those of p53+/- mice. Furthermore, p63+/- mice were not prone to chemically induced tumorigenesis, and p63 expression was maintained in carcinomas. These findings demonstrate that, in agreement with data from human tumors, p63 plays a markedly different biological role in cancer than p53.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Carcinogens pharmacology Disease Susceptibility Gene Expression Regulation Neoplastic Genomic Instability genetics Heterozygote Mice Mice Knockout Molecular Sequence Data Mutation genetics Neoplasms chemically induced genetics metabolism pathology Phosphoproteins deficiency genetics metabolism Trans-Activators deficiency genetics metabolism |
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics organism description > animal > mammal > rodent > mouse bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > p63 bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal |
| CSHL Authors: | |
| Communities: | CSHL labs > Mills lab |
| Depositing User: | CSHL Librarian |
| Date: | 30 May 2006 |
| Date Deposited: | 13 Dec 2011 14:54 |
| Last Modified: | 09 Nov 2017 16:12 |
| PMCID: | PMC1482510 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22836 |
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