Chen, B. L., Chklovskii, D. B. (April 2006) Placement and routing optimization in the brain. Proceedings of the 2006 international symposium on Physical design, 2006. pp. 136-141.
Abstract
Given that brains and computers are similar in many respects, can vast experience in computer engineering help us understand brain design? Here we apply tools developed for physical design of computer chips to understand the layout of the nervous system. Starting with the known wiring diagram of the C. elegans nervous system, we predict the locations of synapses and extent of neurons that minimize the total wiring length. Comparing predicted locations of C. elegans neuronal cell bodies with the actual locations, we find reasonable agreement. Therefore, minimization of wiring length is an important consideration both in chip design and brain architecture. Furthermore, wire length minimization can be used to infer functional roles of neuronal components. Copyright 2006 ACM.
| Item Type: | Paper |
|---|---|
| Subjects: | organism description > animal > C elegans bioinformatics > quantitative biology organs, tissues, organelles, cell types and functions > organs types and functions > brain bioinformatics > genomics and proteomics > computers > computer hardware Publication Type > Meeting Abstract organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse |
| CSHL Authors: | |
| Communities: | CSHL labs > Chklovskii lab School of Biological Sciences > Publications |
| Depositing User: | CSHL Librarian |
| Date: | 9 April 2006 |
| Date Deposited: | 19 Dec 2011 18:20 |
| Last Modified: | 03 Jan 2019 16:03 |
| URI: | https://repository.cshl.edu/id/eprint/22771 |
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