Zilfou, J. T., Spector, M. S., Lowe, S. W.
(November 2005)
Slugging it out: fine tuning the p53-PUMA death connection.
Cell, 123 (4).
pp. 545-8.
ISSN 0092-8674 (Print)
Abstract
In response to DNA damage, the tumor suppressor p53 elicits a complex cellular response. In this issue of Cell, Wu et al. (2005) show that the transcription factor SLUG is induced by p53 and protects hematopoietic progenitor cells from apoptosis triggered by DNA damage. SLUG exerts this protective role by repressing Puma, a proapoptotic target of p53. PUMA is also a key coordinator of apoptosis mediated by both nuclear and cytoplasmic functions of p53 (Chi-puk et al., 2005).
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Animals
Apoptosis physiology
Apoptosis Regulatory Proteins physiology
DNA Damage
Hematopoietic Stem Cells physiology radiation effects
Humans
Mice
Models Biological
Repressor Proteins physiology
Transcription Factors physiology
Tumor Suppressor Protein p53 physiology
Tumor Suppressor Proteins physiology
bcl-2-Associated X Protein physiology
bcl-X Protein physiology |
| Subjects: |
diseases & disorders > cancer
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > hematopoietic cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > hematopoietic cell
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > hematopoietic cell
therapies > stem cells
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Lowe lab
CSHL labs > Spector lab |
| Depositing User: |
CSHL Librarian
|
| Date: |
18 November 2005 |
| Date Deposited: |
20 Dec 2011 17:00 |
| Last Modified: |
01 Mar 2013 21:04 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/22746 |
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