Herbst, A., Hemann, M. T., Tworkowski, K. A., Salghetti, S. E., Lowe, S. W., Tansey, W. P. (February 2005) A conserved element in Myc that negatively regulates its proapoptotic activity. EMBO Rep, 6 (2). pp. 177-83. ISSN 1469-221X (Print)
Abstract
Myc is an oncoprotein transcription factor that promotes cell proliferation and apoptosis. Analysis of highly conserved elements within vertebrate Myc proteins has been instrumental in defining the functions of the Myc protein. Here, we probe the role of a highly conserved, but little studied, element within the central region of c-Myc, termed 'Myc box III' (MbIII). We show that MbIII is important for transcriptional repression by Myc, and for transformation both in vitro and in a mouse model of lymphomagenesis. Curiously, disruption of MbIII decreases transformation activity by increasing the efficiency with which Myc can induce apoptosis, suggesting that MbIII is a negative regulator of programmed cell death. These findings reveal a role for MbIII in Myc biology, and establish that the oncogenic capacity of Myc is linked directly to its ability to temper the apoptotic response.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Apoptosis physiology Cell Proliferation Gene Expression Regulation physiology Humans Lymphoma etiology pathology Mice Protein Structure Tertiary Proto-Oncogene Proteins c-myc genetics metabolism Transcription Genetic physiology |
| Subjects: | diseases & disorders > cancer bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transcription organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: | |
| Communities: | CSHL labs > Lowe lab CSHL labs > Tansey lab |
| Depositing User: | CSHL Librarian |
| Date: | February 2005 |
| Date Deposited: | 12 Jan 2012 19:09 |
| Last Modified: | 03 May 2018 20:40 |
| PMCID: | PMC1299243 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/22592 |
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