Class-specific features of neuronal wiring

Stepanyants, A., Tamas, G., Chklovskii, D. B. (July 2004) Class-specific features of neuronal wiring. Neuron, 43 (2). pp. 251-9. ISSN 0896-6273 (Print)

Abstract

Brain function relies on specificity of synaptic connectivity patterns among different classes of neurons. Yet, the substrates of specificity in complex neuropil remain largely unknown. We search for imprints of specificity in the layout of axonal and dendritic arbors from the rat neocortex. An analysis of 3D reconstructions of pairs consisting of pyramidal cells (PCs) and GABAergic interneurons (GIs) revealed that the layout of GI axons is specific. This specificity is manifested in a relatively high tortuosity, small branch length of these axons, and correlations of their trajectories with the positions of postsynaptic neuron dendrites. Axons of PCs show no such specificity, usually taking a relatively straight course through neuropil. However, wiring patterns among PCs hold a large potential for circuit remodeling and specificity through growth and retraction of dendritic spines. Our results define distinct class-specific rules in establishing synaptic connectivity, which could be crucial in formulating a canonical cortical circuit.

Item Type:	Paper
Uncontrolled Keywords:	Animals Axons physiology ultrastructure Dendrites physiology ultrastructure Image Processing Computer Assisted Imaging Three Dimensional Interneurons metabolism ultrastructure Neocortex cytology physiology ultrastructure Neural Pathways physiology Neurons physiology Pyramidal Cells ultrastructure Rats Rats, Wistar Synapses physiology gamma-Aminobutyric Acid metabolism
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons
CSHL Authors:	Chklovskii, Dmitri B. Stepansky, Asya
Communities:	CSHL labs > Chklovskii lab
Depositing User:	CSHL Librarian
Date:	22 July 2004
Date Deposited:	25 Jan 2012 14:49
Last Modified:	25 Jan 2012 14:49
URI:	https://repository.cshl.edu/id/eprint/22492

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