Shefi, O., Harel, A., Chklovskii, D. B., Ben-Jacob, E., Ayali, A. (June 2004) Biophysical constraints on neuronal branching. Neurocomputing, 58-60. pp. 487-495. ISSN 0925-2312
Abstract
We investigate rules that govern neuronal arborization, specifically the local geometry of the bifurcation of a neurite into its sub-branches. In the present study we set out to determine the relationship between branch diameter and angle. Existing theories are based on minimizing a neuronal volume cost function, or, alternatively, on the equilibrium of mechanical tension forces, which depend on branch diameters. Our experimental results utilizing two-dimensional cultured neural networks partly corroborate both the volume optimization principles and the tension theory. Deviation from pure tension forces equilibrium is explained by an additional force exerted by the anchoring of the junction to the substrate. (C) 2004 Elsevier B.V. All rights reserved.
| Item Type: | Paper |
|---|---|
| Additional Information: | I |
| Uncontrolled Keywords: | neuronal arborization optimization neural network culture locust OPTIMIZATION NETWORKS networks TENSION tension ARBORS arbors CELLS |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors organs, tissues, organelles, cell types and functions > cell types and functions > cell types > dendritic cells > dendritic arbors |
| CSHL Authors: | |
| Communities: | CSHL labs > Chklovskii lab |
| Depositing User: | CSHL Librarian |
| Date: | June 2004 |
| Date Deposited: | 26 Jan 2012 15:05 |
| Last Modified: | 26 Jan 2012 15:05 |
| URI: | https://repository.cshl.edu/id/eprint/22479 |
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