Reigl, M., Alon, U., Chklovskii, D. B. (2004) Search for computational modules in the C. elegans brain. BMC Biol, 2. p. 25. ISSN 1741-7007 (Electronic)
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Abstract
BACKGROUND: Does the C. elegans nervous system contain multi-neuron computational modules that perform stereotypical functions? We attempt to answer this question by searching for recurring multi-neuron inter-connectivity patterns in the C. elegans nervous system's wiring diagram. RESULTS: Our statistical analysis reveals that some inter-connectivity patterns containing two, three and four (but not five) neurons are significantly over-represented relative to the expectations based on the statistics of smaller inter-connectivity patterns. CONCLUSIONS: Over-represented patterns (or motifs) are candidates for computational modules that may perform stereotypical functions in the C. elegans nervous system. These modules may appear in other species and need to be investigated further.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Brain cytolog physiology Caenorhabditis elegans anatomy & histology physiology Nerve Net Neural Networks (Computer) Neurons physiology Synapses physiology Systems Biology |
| Subjects: | organism description > animal > C elegans bioinformatics > computational biology organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons |
| CSHL Authors: | |
| Communities: | CSHL labs > Chklovskii lab |
| Depositing User: | CSHL Librarian |
| Date: | 2004 |
| Date Deposited: | 26 Jan 2012 21:19 |
| Last Modified: | 26 Jan 2012 21:19 |
| URI: | https://repository.cshl.edu/id/eprint/22466 |
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