Lowe, S. W., Cepero, E., Evan, G. (November 2004) Intrinsic tumour suppression. Nature, 432 (7015). pp. 307-15. ISSN 1476-4687 (Electronic)
Abstract
Mutations that drive uncontrolled cell-cycle progression are requisite events in tumorigenesis. But evolution has installed in the proliferative programmes of mammalian cells a variety of innate tumour-suppressive mechanisms that trigger apoptosis or senescence, should proliferation become aberrant. These contingent processes rely on a series of sensors and transducers that act in a coordinated network to target the machinery responsible for apoptosis and cell-cycle arrest at different points. Although oncogenic mutations that disable such networks can have profound and varied effects on tumour evolution, they may leave intact latent tumour-suppressive potential that can be harnessed therapeutically.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Animals Apoptosis Drug Resistance Neoplasm Humans Neoplasms genetics pathology Oncogene Proteins genetics metabolism Tumor Suppressor Protein p53 metabolism |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > mutations bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > genes: types > oncogene |
| CSHL Authors: | |
| Communities: | CSHL labs > Lowe lab |
| Depositing User: | CSHL Librarian |
| Date: | 18 November 2004 |
| Date Deposited: | 01 Feb 2012 14:39 |
| Last Modified: | 01 Feb 2012 14:39 |
| URI: | https://repository.cshl.edu/id/eprint/22428 |
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