Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making

Musall, Simon, Sun, Xiaonan R, Mohan, Hemanth, An, Xu, Gluf, Steven, Li, Shu-Jing, Drewes, Rhonda, Cravo, Emma, Lenzi, Irene, Yin, Chaoqun, Kampa, Björn M, Churchland, Anne K (January 2023) Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making. Nature Neuroscience. ISSN 1097-6256

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Abstract

Understanding how cortical circuits generate complex behavior requires investigating the cell types that comprise them. Functional differences across pyramidal neuron (PyN) types have been observed within cortical areas, but it is not known whether these local differences extend throughout the cortex, nor whether additional differences emerge when larger-scale dynamics are considered. We used genetic and retrograde labeling to target pyramidal tract, intratelencephalic and corticostriatal projection neurons and measured their cortex-wide activity. Each PyN type drove unique neural dynamics, both at the local and cortex-wide scales. Cortical activity and optogenetic inactivation during an auditory decision task revealed distinct functional roles. All PyNs in parietal cortex were recruited during perception of the auditory stimulus, but, surprisingly, pyramidal tract neurons had the largest causal role. In frontal cortex, all PyNs were required for accurate choices but showed distinct choice tuning. Our results reveal that rich, cell-type-specific cortical dynamics shape perceptual decisions.

Item Type:	Paper
Subjects:	Investigative techniques and equipment organs, tissues, organelles, cell types and functions > tissues types and functions > auditory cortex organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > frontal lobe organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons Investigative techniques and equipment > optogenetics organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > pyramidal neurons organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Mohan, Hemanth Gluf, Steven Li, Shujing Drewes, Rhonda Churchland, Anne K. Sun, Xiaonan R. An, Xu
Communities:	CSHL labs > Albeanu lab CSHL labs > Churchland lab CSHL labs > Huang lab CSHL labs > Kepecs lab CSHL labs > Trotman lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	23 January 2023
Date Deposited:	06 Feb 2023 21:08
Last Modified:	10 Jan 2024 20:37
PMCID:	PMC9991922
URI:	https://repository.cshl.edu/id/eprint/40835

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