Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice

Auguste, Yohan SS, Ferro, Austin, Kahng, Jessica A, Xavier, Andre M, Dixon, Jessica R, Vrudhula, Uma, Nichitiu, Anne-Sarah, Rosado, Daniele, Wee, Tse-Luen, Pedmale, Ullas V, Cheadle, Lucas (September 2022) Oligodendrocyte precursor cells engulf synapses during circuit remodeling in mice. Nature Neuroscience. ISSN 1097-6256

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Abstract

Oligodendrocyte precursor cells (OPCs) give rise to myelinating oligodendrocytes throughout life, but the functions of OPCs are not limited to oligodendrogenesis. Here we show that OPCs contribute to thalamocortical presynapse elimination in the developing and adult mouse visual cortex. OPC-mediated synapse engulfment increases in response to sensory experience during neural circuit refinement. Our data suggest that OPCs may regulate synaptic connectivity in the brain independently of oligodendrogenesis.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > sub-cellular tissues: types and functions > synapse
CSHL Authors:	Auguste, Yohan Ferro, Austin Wee, Tse-Luen Pedmale, Vincent Cheadle, Lucas Rosado, Daneile Kahng, Jessica Xavier, Andre Vrudhula, Uma Nichitiu, Anne-Sarah
Communities:	CSHL labs > Pedmale lab CSHL labs > Spector lab CSHL labs > Cheadle lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	28 September 2022
Date Deposited:	07 Oct 2022 00:23
Last Modified:	07 Oct 2022 00:23
URI:	https://repository.cshl.edu/id/eprint/40729

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