Quantitative relationship between cerebrovascular network and neuronal cell types in mice

Wu, Yuan-Ting, Bennett, Hannah C, Chon, Uree, Vanselow, Daniel J, Zhang, Qingguang, Muñoz-Castañeda, Rodrigo, Cheng, Keith C, Osten, Pavel, Drew, Patrick J, Kim, Yongsoo (June 2022) Quantitative relationship between cerebrovascular network and neuronal cell types in mice. Cell Reports, 39 (12). p. 110978. ISSN 2211-1247

[img] PDF
2022-Osten-Quantitative-Relationship-Cerebrovascular.pdf
Available under License Creative Commons Attribution.

Download (11MB)
URL: https://www.ncbi.nlm.nih.gov/pubmed/35732133
DOI: 10.1016/j.celrep.2022.110978

Abstract

The cerebrovasculature and its mural cells must meet brain regional energy demands, but how their spatial relationship with different neuronal cell types varies across the brain remains largely unknown. Here we apply brain-wide mapping methods to comprehensively define the quantitative relationships between the cerebrovasculature, capillary pericytes, and glutamatergic and GABAergic neurons, including neuronal nitric oxide synthase-positive (nNOS+) neurons and their subtypes in adult mice. Our results show high densities of vasculature with high fluid conductance and capillary pericytes in primary motor sensory cortices compared with association cortices that show significant positive and negative correlations with energy-demanding parvalbumin+ and vasomotor nNOS+ neurons, respectively. Thalamo-striatal areas that are connected to primary motor sensory cortices also show high densities of vasculature and pericytes, suggesting dense energy support for motor sensory processing areas. Our cellular-resolution resource offers opportunities to examine spatial relationships between the cerebrovascular network and neuronal cell composition in largely understudied subcortical areas.

Item Type: Paper
Subjects:






organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons
CSHL Authors:
Communities: CSHL labs > Mitra lab
CSHL labs > Osten lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 21 June 2022
Date Deposited: 30 Jun 2022 23:42
Last Modified: 30 Jun 2022 23:42
URI: https://repository.cshl.edu/id/eprint/40669

Actions (login required)

Administrator's edit/view item Administrator's edit/view item
CSHL HomeAbout CSHLResearchEducationNews & FeaturesCampus & Public EventsCareersGiving