Quantitative relationship between cerebrovascular network and neuronal cell types in mice

Wu, Yuan-Ting, Bennett, Hannah C, Chon, Uree, Vanselow, Daniel J, Zhang, Qingguang, Muñoz-Castañeda, Rodrigo, Cheng, Keith C, Osten, Pavel, Drew, Patrick J, Kim, Yongsoo (June 2022) Quantitative relationship between cerebrovascular network and neuronal cell types in mice. Cell Reports, 39 (12). p. 110978. ISSN 2211-1247

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Abstract

The cerebrovasculature and its mural cells must meet brain regional energy demands, but how their spatial relationship with different neuronal cell types varies across the brain remains largely unknown. Here we apply brain-wide mapping methods to comprehensively define the quantitative relationships between the cerebrovasculature, capillary pericytes, and glutamatergic and GABAergic neurons, including neuronal nitric oxide synthase-positive (nNOS+) neurons and their subtypes in adult mice. Our results show high densities of vasculature with high fluid conductance and capillary pericytes in primary motor sensory cortices compared with association cortices that show significant positive and negative correlations with energy-demanding parvalbumin+ and vasomotor nNOS+ neurons, respectively. Thalamo-striatal areas that are connected to primary motor sensory cortices also show high densities of vasculature and pericytes, suggesting dense energy support for motor sensory processing areas. Our cellular-resolution resource offers opportunities to examine spatial relationships between the cerebrovascular network and neuronal cell composition in largely understudied subcortical areas.

Item Type:	Paper
Subjects:	organism description > animal organs, tissues, organelles, cell types and functions > organs types and functions > brain organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > tissues types and functions > cerebral cortex organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons > GABAergic interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > interneurons organism description > animal > mammal organism description > animal > mammal > rodent > mouse organs, tissues, organelles, cell types and functions > organs types and functions organs, tissues, organelles, cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > parvalbumin neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > parvalbumin neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > parvalbumin neurons organism description > animal > mammal > rodent organs, tissues, organelles, cell types and functions > tissues types and functions
CSHL Authors:	Osten, Pavel Munoz-Castaneda, Rodrigo
Communities:	CSHL labs > Mitra lab CSHL labs > Osten lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	21 June 2022
Date Deposited:	30 Jun 2022 23:42
Last Modified:	24 May 2024 15:14
PMCID:	PMC9271215
URI:	https://repository.cshl.edu/id/eprint/40669

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