Ipsaro, Jonathan J, Joshua-Tor, Leemor (February 2022) Developmental roles and molecular mechanisms of Asterix/GTSF1. Wiley Interdisciplinary Reviews: RNA. e1716. ISSN 1757-7004
![]() |
PDF
2022.Ipsaro.Asterix.pdf Available under License Creative Commons Attribution. Download (4MB) |
Abstract
Maintenance of germline genomic integrity is critical for the survival of animal species. Consequently, many cellular and molecular processes have evolved to ensure genetic stability during the production of gametes. Here, we describe the discovery, characterization, and emerging molecular mechanisms of the protein Asterix/Gametocyte-specific factor 1 (GTSF1), an essential gametogenesis factor that is conserved from insects to humans. Beyond its broad importance for healthy germline development, Asterix/GTSF1 has more specific functions in the Piwi-interacting RNA (piRNA)-RNA interference pathway. There, it contributes to the repression of otherwise deleterious transposons, helping to ensure faithful transmission of genetic information to the next generation. This article is categorized under: Regulatory RNAs/RNAi/Riboswitches > RNAi: Mechanisms of Action Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.
Item Type: | Paper |
---|---|
Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > piRNA bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transposons |
CSHL Authors: | |
Communities: | CSHL labs > Joshua-Tor lab |
SWORD Depositor: | CSHL Elements |
Depositing User: | CSHL Elements |
Date: | 2 February 2022 |
Date Deposited: | 10 Feb 2022 16:55 |
Last Modified: | 10 Feb 2022 16:55 |
URI: | https://repository.cshl.edu/id/eprint/40514 |
Actions (login required)
![]() |
Administrator's edit/view item |