Genetically identified amygdala-striatal circuits for valence-specific behaviors

Zhang, Xian, Guan, Wuqiang, Yang, Tao, Furlan, Alessandro, Xiao, Xiong, Yu, Kai, An, Xu, Galbavy, William, Ramakrishnan, Charu, Deisseroth, Karl, Ritola, Kimberly, Hantman, Adam, He, Miao, Josh Huang, Z, Li, Bo (October 2021) Genetically identified amygdala-striatal circuits for valence-specific behaviors. Nature Neuroscience. ISSN 1097-6256

URL: https://www.ncbi.nlm.nih.gov/pubmed/34663958
DOI: 10.1038/s41593-021-00927-0

Abstract

The basolateral amygdala (BLA) plays essential roles in behaviors motivated by stimuli with either positive or negative valence, but how it processes motivationally opposing information and participates in establishing valence-specific behaviors remains unclear. Here, by targeting Fezf2-expressing neurons in the BLA, we identify and characterize two functionally distinct classes in behaving mice, the negative-valence neurons and positive-valence neurons, which innately represent aversive and rewarding stimuli, respectively, and through learning acquire predictive responses that are essential for punishment avoidance or reward seeking. Notably, these two classes of neurons receive inputs from separate sets of sensory and limbic areas, and convey punishment and reward information through projections to the nucleus accumbens and olfactory tubercle, respectively, to drive negative and positive reinforcement. Thus, valence-specific BLA neurons are wired with distinctive input-output structures, forming a circuit framework that supports the roles of the BLA in encoding, learning and executing valence-specific motivated behaviors.

Item Type: Paper
Subjects: organs, tissues, organelles, cell types and functions > tissues types and functions > amygdala
organism description > animal behavior > learning
neurobiology > neuroscience
CSHL Authors:
Communities: CSHL labs > Huang lab
CSHL labs > Li lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 18 October 2021
Date Deposited: 27 Oct 2021 13:42
Last Modified: 01 Nov 2021 14:31
PMCID: PMC8556347
URI: https://repository.cshl.edu/id/eprint/40397

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