Using focal cooling to link neural dynamics and behavior.

Banerjee, Arkarup, Egger, Robert, Long, Michael A (June 2021) Using focal cooling to link neural dynamics and behavior. Neuron. ISSN 0896-6273

DOI: 10.1016/j.neuron.2021.05.029


Establishing a causal link between neural function and behavioral output has remained a challenging problem. Commonly used perturbation techniques enable unprecedented control over intrinsic activity patterns and can effectively identify crucial circuit elements important for specific behaviors. However, these approaches may severely disrupt activity, precluding an investigation into the behavioral relevance of moment-to-moment neural dynamics within a specified brain region. Here we discuss the application of mild focal cooling to slow down intrinsic neural circuit activity while preserving its overall structure. Using network modeling and examples from multiple species, we highlight the power and versatility of focal cooling for understanding how neural dynamics control behavior and argue for its wider adoption within the systems neuroscience community.

Item Type: Paper
Subjects: organism description > animal behavior
bioinformatics > computational biology
neurobiology > neuroscience
CSHL Authors:
Communities: CSHL labs > Banerjee lab
SWORD Depositor: CSHL Elements
Depositing User: CSHL Elements
Date: 19 June 2021
Date Deposited: 30 Jun 2021 13:46
Last Modified: 01 Sep 2021 20:44
PMCID: PMC8376768

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