Using focal cooling to link neural dynamics and behavior.

Banerjee, Arkarup, Egger, Robert, Long, Michael A (June 2021) Using focal cooling to link neural dynamics and behavior. Neuron. ISSN 0896-6273

URL: https://www.ncbi.nlm.nih.gov/pubmed/34171292

DOI: 10.1016/j.neuron.2021.05.029

Abstract

Establishing a causal link between neural function and behavioral output has remained a challenging problem. Commonly used perturbation techniques enable unprecedented control over intrinsic activity patterns and can effectively identify crucial circuit elements important for specific behaviors. However, these approaches may severely disrupt activity, precluding an investigation into the behavioral relevance of moment-to-moment neural dynamics within a specified brain region. Here we discuss the application of mild focal cooling to slow down intrinsic neural circuit activity while preserving its overall structure. Using network modeling and examples from multiple species, we highlight the power and versatility of focal cooling for understanding how neural dynamics control behavior and argue for its wider adoption within the systems neuroscience community.

Item Type:	Paper
Subjects:	bioinformatics organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions bioinformatics > computational biology neurobiology organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons neurobiology > neuroscience organs, tissues, organelles, cell types and functions
CSHL Authors:	Banerjee, Arkarup
Communities:	CSHL labs > Banerjee lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	19 June 2021
Date Deposited:	30 Jun 2021 13:46
Last Modified:	17 Jan 2024 20:08
PMCID:	PMC8376768
URI:	https://repository.cshl.edu/id/eprint/40238

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