Striatal dopamine mediates hallucination-like perception in mice.

Schmack, K, Bosc, M, Ott, T, Sturgill, JF, Kepecs, A (April 2021) Striatal dopamine mediates hallucination-like perception in mice. Science, 372 (6537). eabf4740-eabf4740. ISSN 0036-8075

Abstract

Hallucinations, a central symptom of psychotic disorders, are attributed to excessive dopamine in the brain. However, the neural circuit mechanisms by which dopamine produces hallucinations remain elusive, largely because hallucinations have been challenging to study in model organisms. We developed a task to quantify hallucination-like perception in mice. Hallucination-like percepts, defined as high-confidence false detections, increased after hallucination-related manipulations in mice and correlated with self-reported hallucinations in humans. Hallucination-like percepts were preceded by elevated striatal dopamine levels, could be induced by optogenetic stimulation of mesostriatal dopamine neurons, and could be reversed by the antipsychotic drug haloperidol. These findings reveal a causal role for dopamine-dependent striatal circuits in hallucination-like perception and open new avenues to develop circuit-based treatments for psychotic disorders.

Item Type:	Paper
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dopamine organism description > animal behavior > hallucination organism description > animal > mammal > rodent > mouse Investigative techniques and equipment > optogenetics
CSHL Authors:	Schmack, Katharina Sturgill, James Kepecs, Adam Bosc, Marion
Communities:	CSHL labs > Kepecs lab
SWORD Depositor:	CSHL Elements
Depositing User:	CSHL Elements
Date:	2 April 2021
Date Deposited:	06 May 2021 15:30
Last Modified:	06 May 2021 15:30
URI:	https://repository.cshl.edu/id/eprint/40005

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