p63-related signaling at a glance

Fisher, M. L., Balinth, S., Mills, A. A. (September 2020) p63-related signaling at a glance. J Cell Sci, 133 (17). ISSN 0021-9533 (Print)0021-9533

URL: https://pubmed.ncbi.nlm.nih.gov/32917730/
DOI: 10.1242/jcs.228015


p63 (also known as TP63) is a transcription factor of the p53 family, along with p73. Multiple isoforms of p63 have been discovered and these have diverse functions encompassing a wide array of cell biology. p63 isoforms are implicated in lineage specification, proliferative potential, differentiation, cell death and survival, DNA damage response and metabolism. Furthermore, p63 is linked to human disease states including cancer. p63 is critical to many aspects of cell signaling, and in this Cell science at a glance article and the accompanying poster, we focus on the signaling cascades regulating TAp63 and ΔNp63 isoforms and those that are regulated by TAp63 and ΔNp63, as well the role of p63 in disease.

Item Type: Paper
Additional Information: 1477-9137 Fisher, Matthew L Balinth, Seamus Mills, Alea A Orcid: 0000-0003-4416-6646 R21 OD018332/OD/NIH HHS/United States F32 CA225134/CA/NCI NIH HHS/United States F31 CA247400/CA/NCI NIH HHS/United States P30 CA045508/CA/NCI NIH HHS/United States R01 CA190997/CA/NCI NIH HHS/United States Journal Article Review J Cell Sci. 2020 Sep 11;133(17):jcs228015. doi: 10.1242/jcs.228015.
Uncontrolled Keywords: Cancer Development Differentiation Isoforms Signal transduction Stemness p63
CSHL Authors:
Communities: CSHL labs > Mills lab
Depositing User: Matthew Dunn
Date: 11 September 2020
Date Deposited: 20 Apr 2021 02:32
Last Modified: 20 Apr 2021 02:32
PMCID: PMC7502597
Related URLs:
URI: https://repository.cshl.edu/id/eprint/39855

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