Fisher, M. L., Balinth, S., Mills, A. A.
(September 2020)
p63-related signaling at a glance.
J Cell Sci, 133 (17).
ISSN 0021-9533 (Print)0021-9533
Abstract
p63 (also known as TP63) is a transcription factor of the p53 family, along with p73. Multiple isoforms of p63 have been discovered and these have diverse functions encompassing a wide array of cell biology. p63 isoforms are implicated in lineage specification, proliferative potential, differentiation, cell death and survival, DNA damage response and metabolism. Furthermore, p63 is linked to human disease states including cancer. p63 is critical to many aspects of cell signaling, and in this Cell science at a glance article and the accompanying poster, we focus on the signaling cascades regulating TAp63 and ΔNp63 isoforms and those that are regulated by TAp63 and ΔNp63, as well the role of p63 in disease.
| Item Type: |
Paper
|
| Additional Information: |
1477-9137
Fisher, Matthew L
Balinth, Seamus
Mills, Alea A
Orcid: 0000-0003-4416-6646
R21 OD018332/OD/NIH HHS/United States
F32 CA225134/CA/NCI NIH HHS/United States
F31 CA247400/CA/NCI NIH HHS/United States
P30 CA045508/CA/NCI NIH HHS/United States
R01 CA190997/CA/NCI NIH HHS/United States
Journal Article
Review
J Cell Sci. 2020 Sep 11;133(17):jcs228015. doi: 10.1242/jcs.228015. |
| Uncontrolled Keywords: |
Cancer
Development
Differentiation
Isoforms
Signal transduction
Stemness
p63 |
| Subjects: |
bioinformatics
diseases & disorders
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
diseases & disorders > neoplasms
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organs, tissues, organelles, cell types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > tissues types and functions > signal transduction
organs, tissues, organelles, cell types and functions > tissues types and functions
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > transcription factor |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Mills lab
CSHL Cancer Center Program
CSHL Cancer Center Program > Gene Regulation and Inheritance Program |
| Depositing User: |
Matthew Dunn
|
| Date: |
11 September 2020 |
| Date Deposited: |
20 Apr 2021 02:32 |
| Last Modified: |
13 Feb 2024 21:18 |
| PMCID: |
PMC7502597 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/39855 |
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