Microwave enhancement of a 'one-pot' tandem azidation-'click' cycloaddition of anilines

Moorhouse, A. D., Moses, J. E. (August 2008) Microwave enhancement of a 'one-pot' tandem azidation-'click' cycloaddition of anilines. Synlett (14). pp. 2089-2092. ISSN 0936-5214

URL: https://www.thieme-connect.com/products/ejournals/...
DOI: 10.1055/s-2008-1078019


The practical and efficient one-pot azidation of anilines with the reagent combination t-BuONO and TMSN3 has become a useful addition to the click-chemistry toolbox. Herein we report a modification of this methodology, using microwave radiation to significantly enhance the rate of fori-nation of 1,4-triazoles from in situ generated azides.

Item Type: Paper
Subjects: chemistry > chemicals > anilines
chemistry > chemical synthesis
chemistry > techniques > microwaves
CSHL Authors:
Communities: CSHL labs > Moses lab
Depositing User: Matthew Dunn
Date: 22 August 2008
Date Deposited: 29 Sep 2020 17:14
Last Modified: 29 Sep 2020 17:14
URI: https://repository.cshl.edu/id/eprint/39796

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