ZEBrA - Zebra finch Expression Brain Atlas: a resource for comparative molecular neuroanatomy and brain evolution studies

Lovell, P. V., Wirthlin, M., Kaser, T., Buckner, A. A., Carleton, J. B., Snider, B. R., McHugh, A. K., Tolpygo, A., Mitra, P. P., Mello, C. V. (February 2020) ZEBrA - Zebra finch Expression Brain Atlas: a resource for comparative molecular neuroanatomy and brain evolution studies. J Comp Neurol. ISSN 0021-9967 (Public Dataset)

URL: https://www.ncbi.nlm.nih.gov/pubmed/32037563
DOI: 10.1002/cne.24879

Abstract

An in-depth understanding of the genetics and evolution of brain function and behavior requires detailed mapping of gene expression in functional brain circuits across major vertebrate clades. Here we present the Zebra finch Expression Brain Atlas (ZEBrA; www.zebrafinchatlas.org, RRID: SCR_012988), a web-based resource that maps the expression of genes linked to a broad range of functions onto the brain of zebra finches. ZEBrA is a first of its kind gene expression brain atlas for a bird species, and a first for any sauropsid. ZEBrA's >3,200 high-resolution digital images of in situ hybridized sections for ~650 genes (as of June, 2019) are presented in alignment with an annotated histological atlas and can be browsed down to cellular resolution. An extensive relational database connects expression patterns to information about gene function, mouse expression patterns and phenotypes, and gene involvement in human diseases and communication disorders. By enabling brain-wide gene expression assessments in a bird, ZEBrA provides important substrates for comparative neuroanatomy and molecular brain evolution studies. ZEBrA also provides unique opportunities for linking genetic pathways to vocal learning and motor control circuits, as well as for novel insights into the molecular basis of sex steroids actions, brain dimorphisms, reproductive and social behaviors, sleep function, and adult neurogenesis, among other fundamental themes. This article is protected by copyright. All rights reserved.

Item Type: Paper
Subjects: Investigative techniques and equipment > brain atlas
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons > neuronal circuits
organism description > animal > bird > Zebra Finch
CSHL Authors:
Communities: CSHL labs > Mitra lab
Depositing User: Adrian Gomez
Date: 9 February 2020
Date Deposited: 12 Feb 2020 15:09
Last Modified: 12 Feb 2020 15:09
Related URLs:
Dataset ID:
  • http://www.zebrafinchatlas.org/
URI: https://repository.cshl.edu/id/eprint/38968

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