A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth

Biffi, G., Tuveson, D. A. (May 2019) A FATal Combination: Fibroblast-Derived Lipids and Cancer-Derived Autotaxin Promote Pancreatic Cancer Growth. Cancer Discov, 9 (5). pp. 578-580. ISSN 2159-8274

Abstract

In this issue of Cancer Discovery, Auciello and colleagues find that in the pancreatic cancer microenvironment activated fibroblasts secrete specific lipids that provide a source of biomass production and signaling molecules for cancer cells, fueling their proliferation and migration. Targeting of this stromal-tumor metabolic cross-talk impairs pancreatic cancer progression and represents a new potential therapeutic opportunity.See related article by Auciello et al., p. 617.

Item Type:	Paper
Subjects:	organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts organs, tissues, organelles, cell types and functions > cell types and functions > cell types > fibroblasts diseases & disorders > cancer > cancer types > pancreatic cancer
CSHL Authors:	Tuveson, David A. Biffi, Giulia
Communities:	CSHL labs > Tuveson lab
Depositing User:	Matthew Dunn
Date:	May 2019
Date Deposited:	29 May 2019 18:08
Last Modified:	29 May 2019 18:08
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/37833

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