Dopamine and Cognitive Control in Prefrontal Cortex

Ott, T., Nieder, A. (January 2019) Dopamine and Cognitive Control in Prefrontal Cortex. Trends Cogn Sci, 23 (3). pp. 213-234. ISSN 1364-6613

DOI: 10.1016/j.tics.2018.12.006


Cognitive control, the ability to orchestrate behavior in accord with our goals, depends on the prefrontal cortex. These cognitive functions are heavily influenced by the neuromodulator dopamine. We review here recent insights exploring the influence of dopamine on neuronal response properties in prefrontal cortex (PFC) during ongoing behaviors in primates. This review suggests three major computational roles of dopamine in cognitive control: (i) gating sensory input, (ii) maintaining and manipulating working memory contents, and (iii) relaying motor commands. For each of these roles, we propose a neuronal microcircuit based on known mechanisms of action of dopamine in PFC, which are corroborated by computational network models. This conceptual approach accounts for the various roles of dopamine in prefrontal executive functioning.

Item Type: Paper
Subjects: organism description > animal behavior
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dopamine
organs, tissues, organelles, cell types and functions > tissues types and functions > prefrontal cortex
CSHL Authors:
Communities: CSHL labs > Kepecs lab
Depositing User: Matthew Dunn
Date: 31 January 2019
Date Deposited: 05 Feb 2019 21:07
Last Modified: 04 Mar 2019 20:41
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