Ott, T., Nieder, A.
(January 2019)
Dopamine and Cognitive Control in Prefrontal Cortex.
Trends Cogn Sci, 23 (3).
pp. 213-234.
ISSN 1364-6613
Abstract
Cognitive control, the ability to orchestrate behavior in accord with our goals, depends on the prefrontal cortex. These cognitive functions are heavily influenced by the neuromodulator dopamine. We review here recent insights exploring the influence of dopamine on neuronal response properties in prefrontal cortex (PFC) during ongoing behaviors in primates. This review suggests three major computational roles of dopamine in cognitive control: (i) gating sensory input, (ii) maintaining and manipulating working memory contents, and (iii) relaying motor commands. For each of these roles, we propose a neuronal microcircuit based on known mechanisms of action of dopamine in PFC, which are corroborated by computational network models. This conceptual approach accounts for the various roles of dopamine in prefrontal executive functioning.
| Item Type: |
Paper
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| Subjects: |
bioinformatics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing
bioinformatics > genomics and proteomics
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification
organism description > animal
organism description > animal behavior
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > dopamine
organism description > animal > mammal
organs, tissues, organelles, cell types and functions
organs, tissues, organelles, cell types and functions > tissues types and functions > prefrontal cortex
organism description > animal > mammal > primates
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types
organs, tissues, organelles, cell types and functions > tissues types and functions |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Kepecs lab |
| Depositing User: |
Matthew Dunn
|
| Date: |
31 January 2019 |
| Date Deposited: |
05 Feb 2019 21:07 |
| Last Modified: |
02 Feb 2024 19:44 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/37685 |
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