Connecting the Metabolic and Immune Responses to Cancer

Flint, Thomas R., Fearon, Douglas T., Janowitz, Tobias (May 2017) Connecting the Metabolic and Immune Responses to Cancer. Trends in Molecular Medicine, 23 (5). pp. 451-464. ISSN 1471-4914

DOI: 10.1016/j.molmed.2017.03.001


Separate research fields have advanced our understanding of, on the one hand, cancer immunology and, on the other hand, cachexia, the fatal tumor-induced wasting syndrome. A link between the host’s immune and metabolic responses to cancer remained unexplored. Emerging work in preclinical models of colorectal and pancreatic cancer has unveiled tumor-induced reprogramming of liver metabolism in cachexia that leads to suppression of antitumor immunity and failure of immunotherapy. As research efforts in metabolism and immunology in cancer are rapidly expanding, it is timely to discuss the metabolic and immunological determinants of the cancer–host interaction. We also present the hypothesis that the convergence of host metabolism and antitumor immunity may offer a platform for biomarker-driven investigations of new combination therapies.

Item Type: Paper
Uncontrolled Keywords: cachexia caloric deficiency cancer immunotherapy glucocorticoids hepatic metabolism interleukin-6
Subjects: diseases & disorders > cancer
CSHL Authors:
Communities: CSHL Cancer Center Program > Signal Transduction
CSHL labs > Fearon lab
CSHL labs > Janowitz lab
CSHL Cancer Center Program > Cellular Communication in Cancer Program
Highlight: Janowitz, Tobias
Depositing User: Matt Covey
Date: May 2017
Date Deposited: 10 Apr 2017 21:26
Last Modified: 26 Oct 2020 16:07
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