Ducommun, B., Draetta, G., Young, P., Beach, D. (February 1990) Fission yeast cdc25 is a cell-cycle regulated protein. Biochem Biophys Res Commun, 167 (1). pp. 301-9. ISSN 0006-291X (Print)0006-291X (Linking)
Abstract
Fission yeast cell division is initiated by the cdc2/cdc13-cyclin protein kinase which in its catalytically active state comprises the mitotic inducer. During interphase the cdc2/cyclin complex is assembled in an inactive state that requires cdc25+ gene function for M-phase activation. The cdc25+ product, a 76 kd phosphoprotein, is shown to oscillate in abundance during the cell cycle, reaching a peak at G2/M, and to be sensitive to nitrogen starvation. The level of cdc25 is subject to feedback regulation involving both cdc25 and cdc2.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Blotting, Western Cell Cycle *Cell Cycle Proteins Electrophoresis, Polyacrylamide Gel Escherichia coli/genetics Fungal Proteins/*genetics Gene Expression Genes, Fungal Nitrogen Plasmids Promoter Regions, Genetic Schizosaccharomyces/*genetics *ras-GRF1 |
| Subjects: | organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > cell cycle bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression organism description > yeast |
| CSHL Authors: | |
| Communities: | CSHL labs > Beach lab |
| Depositing User: | Matt Covey |
| Date: | 28 February 1990 |
| Date Deposited: | 04 Apr 2016 14:43 |
| Last Modified: | 04 Apr 2016 14:43 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32285 |
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