Transplantation of Beta-Cells from Transgenic Mice into Nude Athymic Diabetic Rats Restores Glucose Regulation

Hicks, B. A., Stein, R., Efrat, S., Grant, S., Hanahan, D., Demetriou, A. A. (December 1991) Transplantation of Beta-Cells from Transgenic Mice into Nude Athymic Diabetic Rats Restores Glucose Regulation. Diabetes Research and Clinical Practice, 14 (3). pp. 157-164. ISSN 0168-8227

DOI: 10.1016/0168-8227(91)90016-7


We have shown that elevated plasma D-glucose levels in experimentally-induced diabetic nude athymic rats can be reduced by intraperitoneal transplantation of microcarrier-attached insulin producing beta-cells from the mouse pancreatic beta-cell line, beta-TC-1. The reduction in the level of hyperglycemia was observed as early as two days following cell transplantation and was associated with a concomitant increase in plasma insulin levels. beta-TC-1 cell transplanted diabetic rats had plasma D-glucose levels similar to those found in non-diabetic control animals and remained normoglycemic throughout the 39 day experimental period. The beta-TC-1 cell transplanted diabetic rats also had near normalization of body weight, food and water intake and of urine output when compared to control diabetic and non-diabetic rats. Similarly, they exhibited improved blood glucose clearance following intravenous D-glucose administration. These results suggest that beta-TC-1 cells regulate D-glucose homeostasis following transplantation into diabetic rat recipients in a manner similar to that of endogenous pancreatic beta-cells.

Item Type: Paper
Uncontrolled Keywords: beta-cell transplantation streptozotocin induced diabetes insulin-dependent diabetes-mellitus cell therapy rat pancreas transplantation hyperglycemia registry islets
Subjects: diseases & disorders > nutritional and metabolic diseases > diabetes
organism description > animal > mammal > rodent > mouse
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal
CSHL Authors:
Communities: CSHL labs
Depositing User: Matt Covey
Date: December 1991
Date Deposited: 09 Dec 2015 20:46
Last Modified: 09 Dec 2015 20:46
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