Hicks, B. A., Stein, R., Efrat, S., Grant, S., Hanahan, D., Demetriou, A. A. (December 1991) Transplantation of Beta-Cells from Transgenic Mice into Nude Athymic Diabetic Rats Restores Glucose Regulation. Diabetes Research and Clinical Practice, 14 (3). pp. 157-164. ISSN 0168-8227
Abstract
We have shown that elevated plasma D-glucose levels in experimentally-induced diabetic nude athymic rats can be reduced by intraperitoneal transplantation of microcarrier-attached insulin producing beta-cells from the mouse pancreatic beta-cell line, beta-TC-1. The reduction in the level of hyperglycemia was observed as early as two days following cell transplantation and was associated with a concomitant increase in plasma insulin levels. beta-TC-1 cell transplanted diabetic rats had plasma D-glucose levels similar to those found in non-diabetic control animals and remained normoglycemic throughout the 39 day experimental period. The beta-TC-1 cell transplanted diabetic rats also had near normalization of body weight, food and water intake and of urine output when compared to control diabetic and non-diabetic rats. Similarly, they exhibited improved blood glucose clearance following intravenous D-glucose administration. These results suggest that beta-TC-1 cells regulate D-glucose homeostasis following transplantation into diabetic rat recipients in a manner similar to that of endogenous pancreatic beta-cells.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | beta-cell transplantation streptozotocin induced diabetes insulin-dependent diabetes-mellitus cell therapy rat pancreas transplantation hyperglycemia registry islets |
| Subjects: | diseases & disorders > nutritional and metabolic diseases > diabetes organism description > animal > mammal > rodent > mouse bioinformatics > genomics and proteomics > genetics & nucleic acid processing > transgenic animal |
| CSHL Authors: | |
| Communities: | CSHL labs |
| Depositing User: | Matt Covey |
| Date: | December 1991 |
| Date Deposited: | 09 Dec 2015 20:46 |
| Last Modified: | 09 Dec 2015 20:46 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/32166 |
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