Genetic control of pituitary development and hypopituitarism

Zhu, X., Lin, C. R., Prefontaine, G. G., Tollkuhn, J., Rosenfeld, M. G. (June 2005) Genetic control of pituitary development and hypopituitarism. Curr Opin Genet Dev, 15 (3). pp. 332-40. ISSN 0959-437X (Print)0959-437X (Linking)

Abstract

The pituitary gland functions as a relay between the hypothalamus and peripheral target organs that regulate basic physiological functions, including growth, the stress response, reproduction, metabolism and lactation. The development of the pituitary gland has been studied extensively in mice, and has begun to be explored in zebrafish, an animal model system amenable to forward genetics. Multiple signaling molecules and transcription factors, expressed in overlapping but distinct spatial and temporal patterns, are required at various stages of pituitary development. Defects in this precisely regulated genetic program lead to diverse pituitary dysfunction. The animal models have greatly enhanced our understanding of molecular mechanisms underlying pituitary development in addition to congenital pituitary disorders in humans.

Item Type:	Paper
Uncontrolled Keywords:	Animals Gene Expression Regulation, Developmental Humans Hypopituitarism/ genetics/metabolism Pituitary Gland/ embryology/ metabolism Signal Transduction Transcription Factors/genetics/metabolism
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus > hypothalamus organs, tissues, organelles, cell types and functions > tissues types and functions > hypothalamus
CSHL Authors:	Tollkuhn, Jessica
Communities:	CSHL labs > Tollkuhn lab
Depositing User:	Matt Covey
Date:	June 2005
Date Deposited:	23 Jul 2015 18:54
Last Modified:	23 Jul 2015 18:54
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/31660

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