Zhu, X., Lin, C. R., Prefontaine, G. G., Tollkuhn, J., Rosenfeld, M. G.
(June 2005)
Genetic control of pituitary development and hypopituitarism.
Curr Opin Genet Dev, 15 (3).
pp. 332-40.
ISSN 0959-437X (Print)0959-437X (Linking)
Abstract
The pituitary gland functions as a relay between the hypothalamus and peripheral target organs that regulate basic physiological functions, including growth, the stress response, reproduction, metabolism and lactation. The development of the pituitary gland has been studied extensively in mice, and has begun to be explored in zebrafish, an animal model system amenable to forward genetics. Multiple signaling molecules and transcription factors, expressed in overlapping but distinct spatial and temporal patterns, are required at various stages of pituitary development. Defects in this precisely regulated genetic program lead to diverse pituitary dysfunction. The animal models have greatly enhanced our understanding of molecular mechanisms underlying pituitary development in addition to congenital pituitary disorders in humans.
| Item Type: |
Paper
|
| Uncontrolled Keywords: |
Animals
Gene Expression Regulation, Developmental
Humans
Hypopituitarism/ genetics/metabolism
Pituitary Gland/ embryology/ metabolism
Signal Transduction
Transcription Factors/genetics/metabolism |
| Subjects: |
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene expression
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation
bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > genes, structure and function > gene regulation
organs, tissues, organelles, cell types and functions > tissues types and functions > suprachiasmatic nucleus > hypothalamus
organs, tissues, organelles, cell types and functions > tissues types and functions > hypothalamus |
| CSHL Authors: |
|
| Communities: |
CSHL labs > Tollkuhn lab |
| Depositing User: |
Matt Covey
|
| Date: |
June 2005 |
| Date Deposited: |
23 Jul 2015 18:54 |
| Last Modified: |
23 Jul 2015 18:54 |
| Related URLs: |
|
| URI: |
https://repository.cshl.edu/id/eprint/31660 |
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