Anxious moments for the protein tyrosine phosphatase PTP1B

Krishnan, Navasona, Tonks, Nicholas K. (August 2015) Anxious moments for the protein tyrosine phosphatase PTP1B. Trends in Neurosciences, 38 (8). pp. 462-465. ISSN 0166-2236

DOI: 10.1016/j.tins.2015.06.006


Chronic stress can lead to the development of anxiety and mood disorders. Thus, novel therapies for preventing adverse effects of stress are vitally important. Recently, the protein tyrosine phosphatase PTP1B was identified as a novel regulator of stress-induced anxiety. This opens up exciting opportunities to exploit PTP1B inhibitors as anxiolytics.

Item Type: Paper
Uncontrolled Keywords: endocannabinoid signaling stress-induced anxiety protein tyrosine phosphatase PTP1B anxiolytic therapy trodusquemine/MSI-1436 glutamate receptor
Subjects: bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > enzymes > protein tyrosine phosphatase
CSHL Authors:
Communities: CSHL labs > Tonks lab
Depositing User: Matt Covey
Date: 9 August 2015
Date Deposited: 10 Jul 2015 20:50
Last Modified: 11 Sep 2015 15:15
PMCID: PMC4530058
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