Programmed cell death in Caenorhabditis elegans

Hengartner, M. O., Horvitz, H. R. (August 1994) Programmed cell death in Caenorhabditis elegans. Curr Opin Genet Dev, 4 (4). pp. 581-6. ISSN 0959-437X (Print)

DOI: 10.1016/0959-437X(94)90076-F


Programmed cell death in the nematode Caenorhabditis elegans requires the activities of the genes ced-3 and ced-4 and is antagonized by the activity of the gene ced-9. Cloning of these C. elegans genes has shown that two of them encode proteins with similarity to vertebrate cell death genes and has revealed that nematodes and mammals share a common pathway for programmed cell death.

Item Type: Paper
Uncontrolled Keywords: Amino Acid Sequence Animals Apoptosis/ genetics Apoptosis Regulatory Proteins Caenorhabditis elegans/ genetics/ physiology Caenorhabditis elegans Proteins Calcium-Binding Proteins/genetics/physiology Caspases Consensus Sequence Cysteine Proteinase Inhibitors/genetics Genes, Helminth Genes, Viral Helminth Proteins/genetics/physiology Molecular Sequence Data Proto-Oncogene Proteins/genetics/physiology Proto-Oncogene Proteins c-bcl-2 Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Sequence Homology, Amino Acid
Subjects: organism description > animal > C elegans
organs, tissues, organelles, cell types and functions > cell types and functions > cell functions > apoptosis
CSHL Authors:
Communities: CSHL labs > Hengartner lab
Depositing User: Matt Covey
Date: August 1994
Date Deposited: 06 Aug 2015 21:25
Last Modified: 06 Aug 2015 21:25
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