From guide to target: molecular insights into eukaryotic RNA-interference machinery

Ipsaro, J. J., Joshua-Tor, L. (January 2015) From guide to target: molecular insights into eukaryotic RNA-interference machinery. Nat Struct Mol Biol, 22 (1). pp. 20-28. ISSN 1545-9985 (Public Dataset)

Abstract

Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent, specific and ubiquitous means of gene regulation. Through a number of pathways that are conserved in eukaryotes from yeast to humans, small noncoding RNAs direct molecular machinery to silence gene expression. In this Review, we focus on mechanisms and structures that govern RNA silencing in higher organisms. In addition to highlighting recent advances, we discuss parallels and differences among RNAi pathways. Together, the studies reviewed herein reveal the versatility and programmability of RNA-induced silencing complexes and emphasize the importance of both upstream biogenesis and downstream silencing factors.

Item Type:	Paper
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > RNAi organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote organs, tissues, organelles, cell types and functions > cell types and functions > cell types > eukaryote
CSHL Authors:	Ipsaro, Jonathan J. Joshua-Tor, Leemor
Communities:	CSHL labs > Joshua-Tor lab
Depositing User:	Matt Covey
Date:	7 January 2015
Date Deposited:	16 Jan 2015 20:24
Last Modified:	01 Sep 2017 16:01
PMCID:	PMC4450863
Related URLs:	Publisher
Dataset ID:	PDB: 3ADL PDB: 1DI2 PDB: 2YT4 PDB: 4GGJ PDB: 4F3T PDB: 4OLB PDB: 4W5O PDB: 1ZBI PDB: 4CRV PDB: 4CT4 PDB: 4GJM
URI:	https://repository.cshl.edu/id/eprint/31137

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