Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo

Aizenman, C. D., Akerman, C. J., Jensen, K. R., Cline, H. T. (August 2003) Visually driven regulation of intrinsic neuronal excitability improves stimulus detection in vivo. Neuron, 39 (5). pp. 831-842. ISSN 0896-6273

Abstract

Neurons adapt their electrophysiological properties to maintain stable levels of electrical excitability when faced with a constantly changing environment. We find that exposing freely swimming Xenopus tadpoles to 4-5 hr of persistent visual stimulation increases the intrinsic excitability of optic tectal neurons. This increase is correlated with enhanced voltage-gated Na+ currents. The same visual stimulation protocol also induces a polyamine synthesis-dependent reduction in Ca2+-permeable AMPAR-mediated synaptic drive, suggesting that the increased excitability may compensate for this reduction. Accordingly, the change in excitability was prevented by blocking polyamine synthesis during visual stimulation and was rescued when Ca2+-permeable AMPAR-mediated transmission was selectively reduced. The changes in excitability also rendered tectal cells more responsive to synaptic burst stimuli, improving visual stimulus detection. The synaptic and intrinsic adaptations function together to keep tectal neurons within a constant operating range, while making the intact visual system less responsive to background activity yet more sensitive to burst stimuli.

Item Type:	Paper
Uncontrolled Keywords:	LONG-TERM POTENTIATION ACTIVITY-DEPENDENT REGULATION CA1 PYRAMIDAL NEURONS DENDRITIC EXCITABILITY SYNAPTIC TRANSMISSION NEUROTROPHIC FACTOR ELECTRICAL-ACTIVITY QUANTAL AMPLITUDE CULTURED NEURONS OPTIC TECTUM
Subjects:	bioinformatics > genomics and proteomics > genetics & nucleic acid processing > protein structure, function, modification > protein types > AMPA receptor organism description > animal behavior organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions > cell types organs, tissues, organelles, cell types and functions > cell types and functions organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organs, tissues, organelles, cell types and functions > cell types and functions > cell types > neurons organism description > animal behavior > vision organs, tissues, organelles, cell types and functions > tissues types and functions > visual cortex
CSHL Authors:	Aizenman, Carlos D. Akerman, Colin J. Cline, Hollis T. Jensen, Kendall
Communities:	CSHL labs > Cline lab
Depositing User:	Matt Covey
Date:	August 2003
Date Deposited:	11 Jun 2013 14:39
Last Modified:	11 Jun 2013 14:39
Related URLs:	Publisher
URI:	https://repository.cshl.edu/id/eprint/27981

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