Further evidence for altered cerebellar neuronal integrity in schizophrenia

Ende, G., Hubrich, P., Walter, S., Weber-Fahr, W., Kammerer, N., Braus, D. F., Henn, F. A. (April 2005) Further evidence for altered cerebellar neuronal integrity in schizophrenia. Am J Psychiatry, 162 (4). pp. 790-2. ISSN 0002-953X (Print)0002-953X (Linking)

URL: http://www.ncbi.nlm.nih.gov/pubmed/15800155
DOI: 10.1176/appi.ajp.162.4.790


OBJECTIVE: The authors' goal was to investigate the distribution of metabolites and voxel composition in the pons and three cerebellar subregions and compare metabolite integral values and differences in voxel composition between patients with schizophrenia and healthy subjects. METHOD: Proton magnetic resonance spectroscopic imaging was used to study the cerebellum and pons of 14 patients with schizophrenia and 14 healthy comparison subjects. RESULTS: The voxel composition was not significantly different between the groups, but the patients with schizophrenia had significantly lower N-acetylaspartate levels in the cerebellar cortex and vermis. CONCLUSIONS: The lower integral value of N-acetylaspartate in the cerebellar cortex and the vermis of patients with schizophrenia supports the theory of a dysfunctional corticocerebellar-thalamic-cortical circuit in schizophrenia.

Item Type: Paper
Uncontrolled Keywords: Adult Aspartic Acid/ analogs & derivatives/metabolism Cerebellar Cortex/metabolism/physiopathology Cerebellum/ metabolism/physiopathology Female Humans Magnetic Resonance Spectroscopy Male Neural Pathways/metabolism/physiopathology Neurons/metabolism Pons/metabolism/physiopathology Schizophrenia/ diagnosis/metabolism/physiopathology Thalamus/metabolism/physiopathology
Subjects: diseases & disorders
diseases & disorders > mental disorders
diseases & disorders > mental disorders > schizophrenia
CSHL Authors:
Communities: CSHL labs > Henn lab
Depositing User: Matt Covey
Date: April 2005
Date Deposited: 01 Mar 2013 22:11
Last Modified: 01 Mar 2013 22:11
Related URLs:
URI: https://repository.cshl.edu/id/eprint/27669

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