Ende, G., Hubrich, P., Walter, S., Weber-Fahr, W., Kammerer, N., Braus, D. F., Henn, F. A. (April 2005) Further evidence for altered cerebellar neuronal integrity in schizophrenia. Am J Psychiatry, 162 (4). pp. 790-2. ISSN 0002-953X (Print)0002-953X (Linking)
Abstract
OBJECTIVE: The authors' goal was to investigate the distribution of metabolites and voxel composition in the pons and three cerebellar subregions and compare metabolite integral values and differences in voxel composition between patients with schizophrenia and healthy subjects. METHOD: Proton magnetic resonance spectroscopic imaging was used to study the cerebellum and pons of 14 patients with schizophrenia and 14 healthy comparison subjects. RESULTS: The voxel composition was not significantly different between the groups, but the patients with schizophrenia had significantly lower N-acetylaspartate levels in the cerebellar cortex and vermis. CONCLUSIONS: The lower integral value of N-acetylaspartate in the cerebellar cortex and the vermis of patients with schizophrenia supports the theory of a dysfunctional corticocerebellar-thalamic-cortical circuit in schizophrenia.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | Adult Aspartic Acid/ analogs & derivatives/metabolism Cerebellar Cortex/metabolism/physiopathology Cerebellum/ metabolism/physiopathology Female Humans Magnetic Resonance Spectroscopy Male Neural Pathways/metabolism/physiopathology Neurons/metabolism Pons/metabolism/physiopathology Schizophrenia/ diagnosis/metabolism/physiopathology Thalamus/metabolism/physiopathology |
| Subjects: | diseases & disorders diseases & disorders > mental disorders diseases & disorders > mental disorders > schizophrenia |
| CSHL Authors: | |
| Communities: | CSHL labs > Henn lab |
| Depositing User: | Matt Covey |
| Date: | April 2005 |
| Date Deposited: | 01 Mar 2013 22:11 |
| Last Modified: | 01 Mar 2013 22:11 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/27669 |
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