Li, W. H., Jin, Y., Prazak, L., Hammell, M., Dubnau, J. (September 2012) Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders. PLoS ONE, 7 (9). ISSN 1932-6203
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Abstract
Elevated expression of specific transposable elements (TEs) has been observed in several neurodegenerative disorders. TEs also can be active during normal neurogenesis. By mining a series of deep sequencing datasets of protein-RNA interactions and of gene expression profiles, we uncovered extensive binding of TE transcripts to TDP-43, an RNA-binding protein central to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Second, we find that association between TDP-43 and many of its TE targets is reduced in FTLD patients. Third, we discovered that a large fraction of the TEs to which TDP-43 binds become de-repressed in mouse TDP-43 disease models. We propose the hypothesis that TE mis-regulation contributes to TDP-43 related neurodegenerative diseases.
| Item Type: | Paper |
|---|---|
| Uncontrolled Keywords: | l1 retrotransposition rna targets tdp-43 expression brain cells dna mechanisms database neurons |
| Subjects: | bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification diseases & disorders bioinformatics > genomics and proteomics > genetics & nucleic acid processing bioinformatics > genomics and proteomics diseases & disorders > nervous system diseases and disorders bioinformatics > genomics and proteomics > genetics & nucleic acid processing > DNA, RNA structure, function, modification > transposons |
| CSHL Authors: | |
| Communities: | CSHL labs > Dubnau lab CSHL labs > Hammell M. lab CSHL Post Doctoral Fellows |
| Depositing User: | Matt Covey |
| Date: | 5 September 2012 |
| Date Deposited: | 30 Jan 2013 17:40 |
| Last Modified: | 03 May 2013 13:43 |
| PMCID: | PMC3434193 |
| Related URLs: | |
| URI: | https://repository.cshl.edu/id/eprint/26993 |
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